Nuclei Segmentation in histopathological images

Histopathology

Histopathology is the study of change in diseased tissues using a microscopic examination in a biopsy or a surgical specimen. That tissue will be processed and put into a glass slide before inspection. Nuclei segmentation in histopathology images is a very crucial step in cancer diagnosis and grading since it can be a powerful tool in providing the proper treatment.

However, there are certain challenges to histopathological images such as:

  1. Whole slide images (WSI) are very large in size (ranges between 20,000x20,000 pixels to over 100,000x100,000 pixels)
  2. Insufficient annotated images
  3. Dealing with overlapping nuclei
  4. Diversity of Microscopic images

The aim of this project is to improve on nuclei segmentation methods by tackling the problems previously mentioned, which will eventually lead to computer-diagnosis systems that identify and grade cancer.